General Information:

Id: 5,412 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
BTO:0001582 ES-D3 cell
Reference: Qiao LJ et al.(2011) Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/beta-catenin signaling Mol. Cells 32: 437-444 [PMID: 22058016]

Interaction Information:

Comment Osteogenic differentiation of mouse embryonic stem cells (ESCs) by simvastatin was determined by upregulation of the mRNA expression of runtrelated gene 2 (Runx2), osterix (OSX), and osteocalcin (OCN) as osteogenic transcription factors.
Formal Description
Interaction-ID: 52831

drug/chemical compound


increases_expression of



in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin or BGLAP