General Information:

Id: 5,412 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
BTO:0001582 ES-D3 cell
article
Reference: Qiao LJ et al.(2011) Simvastatin promotes osteogenic differentiation of mouse embryonic stem cells via canonical Wnt/beta-catenin signaling Mol. Cells 32: 437-444 [PMID: 22058016]

Interaction Information:

Comment Simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has been known to reduce cholesterol biosynthesis. However, recent studies demonstrate that simvastatin shows diverse cholesterol-independent functions including cellular differentiation. This study investigated the stimulatory effect of simvastatin on the osteogenic differentiation of mouse embryonic stem cells (ESCs). The osteogenic effect of simvastatin was observed at relatively low doses (ranging from 1 nM to 200 nM). Incubation of ESCs in simvastatin-supplemented osteogenic medium significantly increased alkaline phosphatase (ALP) activity at day 7.
Formal Description
Interaction-ID: 52826

drug/chemical compound

Simvastatin

increases_activity of

process

osteogenic differentiation

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, has been known to reduce cholesterol biosynthesis. However, recent studies demonstrate that simvastatin shows diverse cholesterol-independent functions including cellular differentiation. This study investigated the stimulatory effect of simvastatin on the osteogenic differentiation of mouse embryonic stem cells (ESCs). The osteogenic effect of simvastatin was observed at relatively low doses (ranging from 1 nM to 200 nM). Incubation of ESCs in simvastatin-supplemented osteogenic medium significantly increased alkaline phosphatase (ALP) activity at day 7.
Formal Description
Interaction-ID: 52828

drug/chemical compound

Simvastatin

increases_activity of

gene/protein

ALPL

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin
Comment Osteogenic differentiation of mouse embryonic stem cells (ESCs) by simvastatin was determined by upregulation of the mRNA expression of runtrelated gene 2 (Runx2), osterix (OSX), and osteocalcin (OCN) as osteogenic transcription factors.
Formal Description
Interaction-ID: 52829

drug/chemical compound

Simvastatin

increases_expression of

gene/protein

RUNX2

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin
Comment Osteogenic differentiation of mouse embryonic stem cells (ESCs) by simvastatin was determined by upregulation of the mRNA expression of runtrelated gene 2 (Runx2), osterix (OSX), and osteocalcin (OCN) as osteogenic transcription factors.
Formal Description
Interaction-ID: 52830

drug/chemical compound

Simvastatin

increases_expression of

gene/protein

SP7

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin
Comment Osteogenic differentiation of mouse embryonic stem cells (ESCs) by simvastatin was determined by upregulation of the mRNA expression of runtrelated gene 2 (Runx2), osterix (OSX), and osteocalcin (OCN) as osteogenic transcription factors.
Formal Description
Interaction-ID: 52831

drug/chemical compound

Simvastatin

increases_expression of

gene/protein

BGLAP

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin or BGLAP
Comment Simvastatin treatment increased protein expression of OCN, osteopontin (OPN), and collagen type I (Coll I) in embryonic stem cells.
Formal Description
Interaction-ID: 52836

drug/chemical compound

Simvastatin

increases_quantity of

gene/protein

BGLAP

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin or BGLAP
Comment Simvastatin treatment increased protein expression of OCN, osteopontin (OPN), and collagen type I (Coll I) in embryonic stem cells.
Formal Description
Interaction-ID: 52837

drug/chemical compound

Simvastatin

increases_quantity of

gene/protein

SPP1

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin
Comment Simvastatin treatment increased protein expression of OCN, osteopontin (OPN), and collagen type I (Coll I) in embryonic stem cells.
Formal Description
Interaction-ID: 52838

drug/chemical compound

Simvastatin

increases_quantity of

gene/protein

COL1A1

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin or COL1A1
Comment Collectively, these findings suggest that simvastatin enhances the differentiation of embryonic stem cells (ESCs) toward osteogenic lineage through activation of canonical Wnt/beta-catenin signaling.
Formal Description
Interaction-ID: 52842

drug/chemical compound

Simvastatin

increases_activity of

in embryonic stem cells
Drugbank entries Show/Hide entries for Simvastatin
Comment Collectively, these findings suggest that simvastatin enhances the differentiation of embryonic stem cells (ESCs) toward osteogenic lineage through activation of canonical Wnt/beta-catenin signaling.
Formal Description
Interaction-ID: 52843

increases_activity of

process

osteogenic differentiation

in embryonic stem cells