General Information:

Id: 5,411 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
APCmin/+ mouse; non-transformed human colonic cell line (NCM460)
intestinal adenoma
article
Reference: Nagel JM et al.(2012) Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone PLoS ONE 7 [PMID: 22848656]

Interaction Information:

Comment APCmin mice lacking MCH developed fewer, smaller and less dysplastic tumors in the intestine and colon which at the molecular level are characterized by attenuated activation of the wnt/beta-catenin signaling pathway and increased apoptotic indices.
Formal Description
Interaction-ID: 52758

gene/protein

Melanin-concentrating hormone

increases_activity of

process

canonical Wnt signaling pathway

in mouse