CIDeRGeneral Information:
| Id: | 5,410 (click here to show other Interactions for entry) |
| Diseases: |
Cancer
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Garcia-Jimenez C et al.(2013) A new link between diabetes and cancer: enhanced WNT/beta-catenin signaling by high glucose J Mol Endocrinol 52: R51-R66 [PMID: 24049067] |
Interaction Information:
| Comment | WNT stimulation alone is not enough to promote nuclear accumulation of beta-catenin, but this process requires and depends on high glucose to increase its nuclear retention in a variety of human tumor-derived cell lines related to cancers associated with hyperglycemia and diabetes. As nuclear accumulation of beta-catenin is a well-known tumor marker of bad prognosis, constitutive WNT signaling in cancer on one side, and increased glucose uptake by tumor cells on the other, reveals a previously unrecognized requisite for WNT signaling in cancer, namely its amplification by high glucose. The ability of high glucose to amplify WNT/beta-catenin signaling provides a link between cancer and hyperglycemia which is independent of inflammation, hyperinsulinemia, or ROS induced mutations. |
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Formal Description Interaction-ID: 52822 |
process increases_transport of gene/protein |
| Drugbank entries | Show/Hide entries for CTNNB1 |