CIDeRGeneral Information:
| Id: | 5,410 (click here to show other Interactions for entry) |
| Diseases: |
Cancer
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Garcia-Jimenez C et al.(2013) A new link between diabetes and cancer: enhanced WNT/beta-catenin signaling by high glucose J Mol Endocrinol 52: R51-R66 [PMID: 24049067] |
Interaction Information:
| Comment | The WNTs comprise a large family of secreted cys-rich glycoprotein ligands that coordinate cell fate decision-making in a broad range of developmental and homeostatic contexts. WNT proteins bind to their membrane receptors and activate a number of pathways, including planar cell polarity pathway, Ca+ signaling, and the canonical WNT/beta-catenin pathway which is the best known and the most deeply involved in cancer. Notably, aberrant WNT signaling is present in 40–90% gastrointestinal cancers, which are the specific cancer sites more tightly associated with diabetes. |
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Formal Description Interaction-ID: 52806 |
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