General Information:

Id: 5,410 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Garcia-Jimenez C et al.(2013) A new link between diabetes and cancer: enhanced WNT/beta-catenin signaling by high glucose J Mol Endocrinol 52: R51-R66 [PMID: 24049067]

Interaction Information:

Comment The WNTs comprise a large family of secreted cys-rich glycoprotein ligands that coordinate cell fate decision-making in a broad range of developmental and homeostatic contexts. WNT proteins bind to their membrane receptors and activate a number of pathways, including planar cell polarity pathway, Ca+ signaling, and the canonical WNT/beta-catenin pathway which is the best known and the most deeply involved in cancer. Notably, aberrant WNT signaling is present in 40–90% gastrointestinal cancers, which are the specific cancer sites more tightly associated with diabetes.
Formal Description
Interaction-ID: 52806

affects_activity of

disease

Cancer