CIDeRGeneral Information:
| Id: | 5,410 (click here to show other Interactions for entry) |
| Diseases: |
Cancer
Diabetes mellitus, type II - [OMIM] Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Garcia-Jimenez C et al.(2013) A new link between diabetes and cancer: enhanced WNT/beta-catenin signaling by high glucose J Mol Endocrinol 52: R51-R66 [PMID: 24049067] |
Interaction Information:
| Comment | High glucose enhances cancer-associated WNT signaling by allowing nuclear retention and accumulation of transcriptionally active beta-catenin independently of hyperinsulinemia, adipokines, or inflammation. Beta-catenin is a potent transcriptional coactivator targeted to genes involved in proliferation and senescence bypass, among others. Nuclear beta-catenin is a well-known tumor marker of bad prognosis, and therefore the requirement for high glucose by WNT signaling to promote nuclear accumulation of beta-catenin is likely to have a major impact on cancer biology. |
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Formal Description Interaction-ID: 52803 |
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