General Information:

Id: 5,410 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Garcia-Jimenez C et al.(2013) A new link between diabetes and cancer: enhanced WNT/beta-catenin signaling by high glucose J Mol Endocrinol 52: R51-R66 [PMID: 24049067]

Interaction Information:

Comment High glucose enhances cancer-associated WNT signaling by allowing nuclear retention and accumulation of transcriptionally active beta-catenin independently of hyperinsulinemia, adipokines, or inflammation. Beta-catenin is a potent transcriptional coactivator targeted to genes involved in proliferation and senescence bypass, among others. Nuclear beta-catenin is a well-known tumor marker of bad prognosis, and therefore the requirement for high glucose by WNT signaling to promote nuclear accumulation of beta-catenin is likely to have a major impact on cancer biology.
Formal Description
Interaction-ID: 52803

phenotype

hyperglycemia

increases_activity of