General Information:

Id: 534 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0004102 cerebral cortical neuron
article
Reference: Rudrabhatla P et al.(2008) Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. J. Biol. Chem. 283 [PMID: 18635547]

Interaction Information:

Comment The H2O2 and heat shock induced perikaryal phospho-NF-H accumulations, and neuronal apoptosis was rescued by inhibition of Pin1 in cortical neurons.
Formal Description
Interaction-ID: 2776

drug/chemical compound

H2O2

increases_activity of

Comment JNK3, a brain-specific JNK isoform, is activated under oxidative and heat stresses, and inhibition of Pin1 by Pin1 short interference RNA and DN-Pin1 inhibits this pathway.
Formal Description
Interaction-ID: 2783

drug/chemical compound

H2O2

increases_activity of

gene/protein

MAPK10

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