General Information:

Id: 534
Diseases: Alzheimer disease - [OMIM]
Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0004102 cerebral cortical neuron
article
Reference: Rudrabhatla P et al.(2008) Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. J. Biol. Chem. 283 [PMID: 18635547]

Interaction Information:

Comment The treatment of cultured neuronal cells with H2O2 induces perikaryal accumulation of the NF phosphoepitopes that are normally confined to axons, and these effects are prevented by inhibition of Pin1 with Pin1 siRNA. In unstressed control neurons, p-NF-H (phosphorylated NF-H) is predominantly localized to axonal compartments, with no staining in the cell bodies.
Formal Description
Interaction-ID: 2687

protein modification

NEFH-mod

is localized in

cellular component

axon

in unstressed neurons
Comment The treatment of cultured neuronal cells with H2O2 induces perikaryal accumulation of the NF phosphoepitopes that are normally confined to axons, and these effects are prevented by inhibition of Pin1 with Pin1 siRNA. When cortical neurons are subjected to H2O2 stress, p-NF-H (phosphorylated NF-H) is predominantly localized in cell bodies.
Formal Description
Interaction-ID: 2690

protein modification

NEFH-mod

is localized in

cellular component

perikaryon

in response to H2O2 stress
Comment Pin1 was detected in the cell bodies and axons, and there was a strong colocalization of Pin1 and p-NF-H in the cell bodies with H2O2 stress.
Formal Description
Interaction-ID: 2692

gene/protein

PIN1

is localized in

cellular component

axon

Drugbank entries Show/Hide entries for PIN1
Comment Pin1 was detected in the cell bodies and axons, and there was a strong colocalization of Pin1 and p-NF-H in the cell bodies with H2O2 stress.
Formal Description
Interaction-ID: 2693

gene/protein

PIN1

is localized in

cellular component

perikaryon

Drugbank entries Show/Hide entries for PIN1
Comment Pin1 was detected in the cell bodies and axons, and there was a strong colocalization of Pin1 and p-NF-H in the cell bodies with H2O2 stress.
Formal Description
Interaction-ID: 2694

gene/protein

PIN1

interacts (colocalizes) with

protein modification

NEFH-mod

in cell bodies; in response to H2O2 stress
Drugbank entries Show/Hide entries for PIN1
Comment The treatment of cultured neuronal cells with heat shock enhanced phosphorylated NF-H in neuronal perikarya.
Formal Description
Interaction-ID: 2769

protein modification

NEFH-mod

is localized in

cellular component

perikaryon

in response to heat shock
Comment Confocal images showed a strong colocalization of p-NF-H with Pin1 in heat-stressed perikarya.
Formal Description
Interaction-ID: 2773

gene/protein

PIN1

interacts (colocalizes) with

protein modification

NEFH-mod

in perikarya; in response to heat shock
Drugbank entries Show/Hide entries for PIN1
Comment The H2O2 and heat shock induced perikaryal phospho-NF-H accumulations, and neuronal apoptosis was rescued by inhibition of Pin1 in cortical neurons.
Formal Description
Interaction-ID: 2776

drug/chemical compound

H2O2

increases_activity of

Comment The H2O2 and heat shock induced perikaryal phospho-NF-H accumulations, and neuronal apoptosis was rescued by inhibition of Pin1 in cortical neurons.
Formal Description
Interaction-ID: 2778

increases_activity of

Comment The H2O2 and heat shock induced perikaryal phospho-NF-H accumulations, and neuronal apoptosis was rescued by inhibition of Pin1 in cortical neurons.
Formal Description
Interaction-ID: 2780

gene/protein

PIN1

increases_activity of

in response to H2O2 stress
Drugbank entries Show/Hide entries for PIN1
Comment The H2O2 and heat shock induced perikaryal phospho-NF-H accumulations, and neuronal apoptosis was rescued by inhibition of Pin1 in cortical neurons.
Formal Description
Interaction-ID: 2781

gene/protein

PIN1

increases_activity of

in response to heat shock
Drugbank entries Show/Hide entries for PIN1
Comment JNK3, a brain-specific JNK isoform, is activated under oxidative and heat stresses, and inhibition of Pin1 by Pin1 short interference RNA and DN-Pin1 inhibits this pathway.
Formal Description
Interaction-ID: 2783

drug/chemical compound

H2O2

increases_activity of

gene/protein

MAPK10

Drugbank entries Show/Hide entries for MAPK10
Comment JNK3, a brain-specific JNK isoform, is activated under oxidative and heat stresses, and inhibition of Pin1 by Pin1 short interference RNA and DN-Pin1 inhibits this pathway.
Formal Description
Interaction-ID: 2786

increases_activity of

gene/protein

MAPK10

Drugbank entries Show/Hide entries for MAPK10
Comment The H2O2 stress-increased c-Jun phosphorylation by JNK3 is inhibited by inhibition of Pin1 by Pin1 siRNA and DN-Pin1 and JNK inhibitor SP600125.
Formal Description
Interaction-ID: 2795

gene/protein

PIN1

increases_activity of

gene/protein

MAPK10

in response to H2O2 stress
Drugbank entries Show/Hide entries for PIN1 or MAPK10
Comment The heat stress-increased c-Jun phosphorylation by JNK3 is inhibited by inhibition of Pin1 by Pin1 siRNA and DN-Pin1 and JNK inhibitor SP600125.
Formal Description
Interaction-ID: 2799

gene/protein

PIN1

increases_activity of

gene/protein

MAPK10

in response to heat shock
Drugbank entries Show/Hide entries for PIN1 or MAPK10