General Information:

Id: 5,324
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Leto D and Saltiel AR(2012) Regulation of glucose transport by insulin: traffic control of GLUT4 Nat. Rev. Mol. Cell Biol. 13: 383-396 [PMID: 22617471]

Interaction Information:

Comment Insulin binds to insulin receptor and recruits the adaptor protein APS, which also binds with high affinity to the activated insulin receptor.
Formal Description
Interaction-ID: 52061

complex/PPI

Insulin

interacts (colocalizes) with

complex/PPI

Insulin receptor

Comment Insulin binds to insulin receptor and recruits the adaptor protein APS, which also binds with high affinity to the activated insulin receptor.
Formal Description
Interaction-ID: 52062

gene/protein

INSR

interacts (colocalizes) with

gene/protein

SH2B2

Drugbank entries Show/Hide entries for INSR
Comment Following insulin receptor phosphorylation, APS recruits a complex that comprises the proto-oncogene c-CBL and c-CBL-associated protein (CAP).
Formal Description
Interaction-ID: 52063

gene/protein

SH2B2

increases_activity of

complex/PPI

CBL-SORBS1 complex

Comment c-CBL then interacts with the adaptor protein CRK, which is in complex with the C3G.
Formal Description
Interaction-ID: 52064

gene/protein

CBL

interacts (colocalizes) with

complex/PPI

CRKII-C3G complex

Comment c-CBL then interacts with the adaptor protein CRK, which is in complex with the C3G.
Formal Description
Interaction-ID: 52065

gene/protein

RAPGEF1

is_part_of

complex/PPI

CRKII-C3G complex

Comment C3G in turn catalyses the activation of TC10, a member of the RHO-family of small GTPases that is localized in lipid rafts in the plasma membrane.
Formal Description
Interaction-ID: 52067

gene/protein

RAPGEF1

increases_activity of

gene/protein

RHOQ

Comment Active TC10 interacts with effector protein EXO70, which is a subunit of the exocyst tethering complex, has been implicated in GLUT4 vesicle targeting.
Formal Description
Interaction-ID: 52070

gene/protein

RHOQ

interacts (colocalizes) with

gene/protein

EXOC7

Comment Active TC10 interacts with effector protein EXO70, which is a subunit of the exocyst tethering complex, has been implicated in GLUT4 vesicle targeting.
Formal Description
Interaction-ID: 52071

gene/protein

EXOC7

affects transport of

gene/protein

SLC2A4

Comment Active TC10 interacts with effector protein EXO70, which is a subunit of the exocyst tethering complex, has been implicated in GLUT4 vesicle targeting.
Formal Description
Interaction-ID: 52072

gene/protein

EXOC7

affects_activity of