General Information:

Id: 5,320 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Mus musculus
BTO:0001169 3T3-F442A cell
article
Reference: VanRenterghem B et al.(1998) Interaction of insulin receptor substrate-1 with the sigma3A subunit of the adaptor protein complex-3 in cultured adipocytes J. Biol. Chem. 273 [PMID: 9792713]

Interaction Information:

Comment A cDNA clone that encodes sigma3A, a small subunit of the AP-3 adaptor protein complex, was demonstrated to bind IRS-1 utilizing this cloning strategy. The specific interaction between IRS-1 and sigma3A was further verified by in vitro binding studies employing baculovirus-expressed IRS-1 and a glutathione S-transferase (GST)-sigma3A fusion protein. IRS-1 and sigma3A were found to co-fractionate in a detergent-resistant population of low density membranes isolated from basal 3T3-L1 adipocytes. Importantly, the addition of exogenous purified GST-sigma3A to low density membranes caused the release of virtually all of the IRS-1 bound to these membranes, while GST alone had no effect.
Formal Description
Interaction-ID: 52053

gene/protein

IRS1

interacts (colocalizes) with

gene/protein

AP3S1

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