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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	5,319
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mammalia
Publication type:	article
Reference:	Mackenzie RW and Elliott BT(2014) Akt/PKB activation and insulin signaling: a novel insulin signaling pathway in the treatment of type 2 diabetes Diabetes Metab Syndr Obes 7: 55-64 [PMID: 24611020]

Interaction Information:

Comment	Upon activation, Akt/PKB phosphorylates AS160, leading to a reduction in Rab-GAP activity, promoting GLUT-4 translocation and glucose uptake.
Formal Description Interaction-ID: 52050	gene/protein AKT3 increases_phosphorylation of gene/protein TBC1D4

Comment	Upon activation, Akt/PKB phosphorylates AS160, leading to a reduction in Rab-GAP activity, promoting GLUT-4 translocation and glucose uptake.
Formal Description Interaction-ID: 52051	gene/protein TBC1D4 increases_transport of gene/protein SLC2A4

Comment	Upon activation, Akt/PKB phosphorylates AS160, leading to a reduction in Rab-GAP activity, promoting GLUT-4 translocation and glucose uptake.
Formal Description Interaction-ID: 52052	gene/protein SLC2A4 affects_activity of process glucose import

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