General Information:

Id: 5,314 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Arany Z et al.(2008) HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha Nature 451: 1008-1012 [PMID: 18288196]

Interaction Information:

Comment To investigate a possible role for PGC-1alpha in ischaemia, cultured C2C12 myotubes were deprived of nutrients and maintained in 0.2% oxygen. This led within 3h to an induction of more than tenfold in PGC-1alpha mRNA, as measured by quantitative PCR, and an increase in PGC-1alpha protein, as detected by western blotting. The expression of PGC-1alpha remained elevated when treatment was continued for 48 h and returned to baseline within 3h after restoration of complete medium and 21% oxygen. This induction of PGC-1alpha was not unique to C2C12 myotubes and was observed in nearly all cell lines tested, including fibroblasts, striatal neurons, hepatocytes and primary skeletal muscle cells. Either removal of nutrients or placement in 0.2% oxygen alone led to a threefold induction of PGC-1alpha expression, whereas the combined treatment led to a synergistic 12-fold induction.
Formal Description
Interaction-ID: 52490

increases_expression of

gene/protein

PPARGC1A