CIDeRGeneral Information:
| Id: | 5,299 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| article | |
| Reference: | Thom R et al.(2014) Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha J. Biol. Chem. 13: 8810-8817 [PMID: 24505137] |
Interaction Information:
| Comment | Primary myoblasts were made to differentiate in cell culture, and were then treated with 0.5% oxygen for 16 h, versus normoxic control. Activation of a hypoxic program was confirmed by measuring expression of VEGF, Glut1, and PDK1, genes well known to be induced by hypoxia. Hypoxia induced the expression of alternatively spliced PGC-1alpha 8-fold. The expression of full length PGC-1alpha, on the other hand, was unaltered by hypoxic treatment. Hypoxia thus preferentially induces alternatively spliced PGC-1alpha expression in skeletal muscle cells. |
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Formal Description Interaction-ID: 51799 |
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| Drugbank entries | Show/Hide entries for VEGFA |
| Comment | Primary myoblasts were made to differentiate in cell culture, and were then treated with 0.5% oxygen for 16 h, versus normoxic control. Activation of a hypoxic program was confirmed by measuring expression of VEGF, Glut1, and PDK1, genes well known to be induced by hypoxia. Hypoxia induced the expression of alternatively spliced PGC-1alpha 8-fold. The expression of full length PGC-1alpha, on the other hand, was unaltered by hypoxic treatment. Hypoxia thus preferentially induces alternatively spliced PGC-1alpha expression in skeletal muscle cells. |
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Formal Description Interaction-ID: 51864 |
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| Comment | Primary myoblasts were made to differentiate in cell culture, and were then treated with 0.5% oxygen for 16 h, versus normoxic control. Activation of a hypoxic program was confirmed by measuring expression of VEGF, Glut1, and PDK1, genes well known to be induced by hypoxia. Hypoxia induced the expression of alternatively spliced PGC-1alpha 8-fold. The expression of full length PGC-1alpha, on the other hand, was unaltered by hypoxic treatment. Hypoxia thus preferentially induces alternatively spliced PGC-1alpha expression in skeletal muscle cells. |
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Formal Description Interaction-ID: 51865 |
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| Drugbank entries | Show/Hide entries for PDK1 |
| Comment | Primary myoblasts were made to differentiate in cell culture, and were then treated with 0.5% oxygen for 16 h, versus normoxic control. Activation of a hypoxic program was confirmed by measuring expression of VEGF, Glut1, and PDK1, genes well known to be induced by hypoxia. Hypoxia induced the expression of alternatively spliced PGC-1alpha 8-fold. The expression of full length PGC-1alpha, on the other hand, was unaltered by hypoxic treatment. Hypoxia thus preferentially induces alternatively spliced PGC-1alpha expression in skeletal muscle cells. |
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Formal Description Interaction-ID: 51866 |
process increases_expression of mRNA/protein variant |
| Comment | Primary myoblasts were made to differentiate in cell culture, and were then treated with 0.5% oxygen for 16 h, versus normoxic control. Activation of a hypoxic program was confirmed by measuring expression of VEGF, Glut1, and PDK1, genes well known to be induced by hypoxia. Hypoxia induced the expression of alternatively spliced PGC-1alpha 8-fold. The expression of full length PGC-1alpha, on the other hand, was unaltered by hypoxic treatment. Hypoxia thus preferentially induces alternatively spliced PGC-1alpha expression in skeletal muscle cells. |
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Formal Description Interaction-ID: 51867 |
process increases_expression of mRNA/protein variant |
| Comment | Primary myoblasts were made to differentiate in cell culture, and were then treated with 0.5% oxygen for 16 h, versus normoxic control. Activation of a hypoxic program was confirmed by measuring expression of VEGF, Glut1, and PDK1, genes well known to be induced by hypoxia. Hypoxia induced the expression of alternatively spliced PGC-1alpha 8-fold. The expression of full length PGC-1alpha, on the other hand, was unaltered by hypoxic treatment. Hypoxia thus preferentially induces alternatively spliced PGC-1alpha expression in skeletal muscle cells. |
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Formal Description Interaction-ID: 51868 |
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