General Information:

Id: 5,299 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Thom R et al.(2014) Hypoxic induction of vascular endothelial growth factor (VEGF) and angiogenesis in muscle by truncated peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha J. Biol. Chem. 13: 8810-8817 [PMID: 24505137]

Interaction Information:

Comment Primary myoblasts were made to differentiate in cell culture, and were then treated with 0.5% oxygen for 16 h, versus normoxic control. Activation of a hypoxic program was confirmed by measuring expression of VEGF, Glut1, and PDK1, genes well known to be induced by hypoxia. Hypoxia induced the expression of alternatively spliced PGC-1alpha 8-fold. The expression of full length PGC-1alpha, on the other hand, was unaltered by hypoxic treatment. Hypoxia thus preferentially induces alternatively spliced PGC-1alpha expression in skeletal muscle cells.
Formal Description
Interaction-ID: 51865

increases_expression of



in skeletal muscle
Drugbank entries Show/Hide entries for PDK1