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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	5,298 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Gender:	male
Organism Model:	MKO: skeletal muscle-specific PGC-1alpha knockout mouse
Publication type:	article
Reference:	Handschin C et al.(2007) Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk J. Clin. Invest. 117: 3463-3474 [PMID: 17932564]

Interaction Information:

Comment	IL-6 only inhibits glucose-stimulated insulin secretion, and does not extend to other secretagogues.
Formal Description Interaction-ID: 51854	gene/protein IL6 decreases_activity of process insulin secretion involved in cellular response to glucose stimulus
Drugbank entries	Show/Hide entries for IL6
Drugbank DB01404	Ginseng antagonist IL6
Drugbank DB01404	Ginseng antagonist IL6

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