General Information:

Id: 5,289 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Santulli G et al.(2012) Age-related impairment in insulin release: the essential role of beta(2)-adrenergic receptor Diabetes 61: 692-701 [PMID: 22315324]

Interaction Information:

Comment With aging, wild-type beta2AR+/+ littermates developed impaired insulin secretion and glucose tolerance. Moreover, islets from 20-month-old beta2AR+/+ mice exhibited reduced density of beta2AR compared with those from younger animals, paralleled by decreased levels of PPARgamma, PDX-1, and GLUT2.
Formal Description
Interaction-ID: 51793

process

aging

decreases_activity of

via decreased ADRB2 density