CIDeRGeneral Information:
| Id: | 5,289 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance |
| Mus musculus | |
| male | |
| article | |
| Reference: | Santulli G et al.(2012) Age-related impairment in insulin release: the essential role of beta(2)-adrenergic receptor Diabetes 61: 692-701 [PMID: 22315324] |
Interaction Information:
| Comment | This study investigated the significance of beta2-adrenergic receptor (beta2AR) in age-related impaired insulin secretion and glucose homeostasis. Adult beta2AR-/- mice featured glucose intolerance, and pancreatic islets isolated from these animals displayed impaired glucose-induced insulin release, accompanied by reduced expression of peroxisome proliferator-activated receptor PPARgamma, pancreatic duodenal homeobox-1 (PDX-1), and GLUT2. Overexpression of beta2AR in aged mice rescued glucose intolerance and insulin release both in vivo and ex vivo, restoring PPARgamma/PDX-1/GLUT2 levels. These data indicate that reduced beta2AR expression contributes to the age-related decline of glucose tolerance in mice. |
|
Formal Description Interaction-ID: 51787 |
gene/protein increases_activity of |
| Drugbank entries | Show/Hide entries for ADRB2 |
| Comment | With aging, wild-type beta2AR+/+ littermates developed impaired insulin secretion and glucose tolerance. Moreover, islets from 20-month-old beta2AR+/+ mice exhibited reduced density of beta2AR compared with those from younger animals, paralleled by decreased levels of PPARgamma, PDX-1, and GLUT2. |
|
Formal Description Interaction-ID: 51793 |
process decreases_activity of |