General Information:

Id: 5,289 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
article
Reference: Santulli G et al.(2012) Age-related impairment in insulin release: the essential role of beta(2)-adrenergic receptor Diabetes 61: 692-701 [PMID: 22315324]

Interaction Information:

Comment This study investigated the significance of beta2-adrenergic receptor (beta2AR) in age-related impaired insulin secretion and glucose homeostasis. Adult beta2AR-/- mice featured glucose intolerance, and pancreatic islets isolated from these animals displayed impaired glucose-induced insulin release, accompanied by reduced expression of peroxisome proliferator-activated receptor PPARgamma, pancreatic duodenal homeobox-1 (PDX-1), and GLUT2. Overexpression of beta2AR in aged mice rescued glucose intolerance and insulin release both in vivo and ex vivo, restoring PPARgamma/PDX-1/GLUT2 levels. These data indicate that reduced beta2AR expression contributes to the age-related decline of glucose tolerance in mice.
Formal Description
Interaction-ID: 51787
Drugbank entries Show/Hide entries for ADRB2
Comment With aging, wild-type beta2AR+/+ littermates developed impaired insulin secretion and glucose tolerance. Moreover, islets from 20-month-old beta2AR+/+ mice exhibited reduced density of beta2AR compared with those from younger animals, paralleled by decreased levels of PPARgamma, PDX-1, and GLUT2.
Formal Description
Interaction-ID: 51793

process

aging

decreases_activity of

via decreased ADRB2 density