General Information:

Id: 5,266 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Mus musculus
article/cited
Reference: Robin NC et al.(2013) Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/beta-Catenin Signaling Stem Cell Reports 2: 9-17 [PMID: 24511465]

Interaction Information:

Comment Statins, via inhibition of the sterol biosynthetic pathway (via antagonizing HMGCR), deplete cellular pools of cholesterol, FPP, and GGPP. (cited information)
Formal Description
Interaction-ID: 51354

drug/chemical compound

Statin

decreases_quantity of

drug/chemical compound

Geranylgeranyl pyrophosphate

via antagonizing HMGCR