General Information:

Id: 5,266 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Mus musculus
article/cited
Reference: Robin NC et al.(2013) Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/beta-Catenin Signaling Stem Cell Reports 2: 9-17 [PMID: 24511465]

Interaction Information:

Comment Statins enhance Wnt signaling through regulation of isoprenoid synthesis and not through cholesterol.
Formal Description
Interaction-ID: 51324

drug/chemical compound

Statin

increases_activity of

through regulation of isoprenoid synthesis and not through cholesterol
Comment Statins enhance Wnt signaling through regulation of isoprenoid synthesis and not through cholesterol.
Formal Description
Interaction-ID: 51325

drug/chemical compound

Statin

affects_activity of

Comment Statins enhance Wnt signaling through regulation of isoprenoid synthesis and not through cholesterol.
Formal Description
Interaction-ID: 51326

drug/chemical compound

Statin

NOT affects_activity of

Comment Statins antagonize HMG-CoA-reductase (HMGCR), the rate-limiting enzyme in the sterol biosynthetic pathway. HMGCR loss of function is sufficient to enhance the Wnt pathway. (cited information)
Formal Description
Interaction-ID: 51340

drug/chemical compound

Statin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for HMGCR
Comment Statins, via inhibition of the sterol biosynthetic pathway (via antagonizing HMGCR), deplete cellular pools of cholesterol, FPP, and GGPP. (cited information)
Formal Description
Interaction-ID: 51353

drug/chemical compound

Statin

decreases_quantity of

drug/chemical compound

Farnesyl pyrophosphate

via antagonizing HMGCR
Comment Statins, via inhibition of the sterol biosynthetic pathway (via antagonizing HMGCR), deplete cellular pools of cholesterol, FPP, and GGPP. (cited information)
Formal Description
Interaction-ID: 51354

drug/chemical compound

Statin

decreases_quantity of

drug/chemical compound

Geranylgeranyl pyrophosphate

via antagonizing HMGCR
Comment Statins, via inhibition of the sterol biosynthetic pathway (via antagonizing HMGCR), deplete cellular pools of cholesterol, FPP, and GGPP. (cited information)
Formal Description
Interaction-ID: 51355

drug/chemical compound

Statin

decreases_quantity of

drug/chemical compound

Cholesterol

via antagonizing HMGCR
Drugbank entries Show/Hide entries for