General Information:

Id: 5,266 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Mus musculus
article/cited
Reference: Robin NC et al.(2013) Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/beta-Catenin Signaling Stem Cell Reports 2: 9-17 [PMID: 24511465]

Interaction Information:

Comment Providing initial insight, we show that HMGCR loss of function is sufficient to enhance the Wnt pathway. Furthermore, we demonstrate that simva acts on Wnt signaling by depleting isoprenoids, rather than through a cholesterol-dependent mechanism.
Formal Description
Interaction-ID: 51348

gene/protein

HMGCR

decreases_activity of

process

canonical Wnt signaling pathway

HMGCR loss of function is sufficient to enhance the Wnt pathway.
Drugbank entries Show/Hide entries for HMGCR