CIDeRGeneral Information:
| Id: | 5,266 (click here to show other Interactions for entry) |
| Diseases: |
Alzheimer disease
- [OMIM]
Metabolic |
| Mus musculus | |
| article/cited | |
| Reference: | Robin NC et al.(2013) Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/beta-Catenin Signaling Stem Cell Reports 2: 9-17 [PMID: 24511465] |
Interaction Information:
| Comment | Oral administration of simvastatin in mice enhances Wnt signaling and that this elevation of Wnt signaling is required for the neurogenic effects of simvastatin. |
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Formal Description Interaction-ID: 51321 |
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| Drugbank entries | Show/Hide entries for Simvastatin |
| Comment | Statins enhance Wnt signaling through regulation of isoprenoid synthesis and not through cholesterol. |
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Formal Description Interaction-ID: 51324 |
drug/chemical compound Statin increases_activity of process |
| Comment | Statins enhance Wnt signaling through regulation of isoprenoid synthesis and not through cholesterol. |
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Formal Description Interaction-ID: 51327 |
process affects_activity of process |
| Comment | Statins enhance Wnt signaling through regulation of isoprenoid synthesis and not through cholesterol-dependent mechanism. |
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Formal Description Interaction-ID: 51332 |
drug/chemical compound NOT affects_activity of process |
| Drugbank entries | Show/Hide entries for Cholesterol |
| Comment | Recently was reported that lovastatin and fluvastatin enhance Wnt signaling. (cited information) |
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Formal Description Interaction-ID: 51338 |
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| Drugbank entries | Show/Hide entries for Lovastatin |
| Comment | Recently was reported that lovastatin and fluvastatin enhance Wnt signaling. (cited information) |
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Formal Description Interaction-ID: 51339 |
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| Drugbank entries | Show/Hide entries for Fluvastatin |
| Comment | Simva (=simvastatin) enhances Wnt signaling via depletion of isoprenoids and not cholesterol. Oral simva treatment enhances Wnt signaling in the mammalian adult hippocampus. This is significant in that aside from lithium, no other clinically approved compound has been demonstrated to enhance Wnt signaling in the brain. Addition of GGPP or FPP to simva-treated cells significantly reduced simva-mediated Wnt enhancement, while squalene did not have an effect. Since FPP is used to synthesize GGPP, the effect may be due to depletion of GGPP alone or a combination of FPP and GGPP depletion. |
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Formal Description Interaction-ID: 51343 |
drug/chemical compound increases_activity of process |
| Drugbank entries | Show/Hide entries for Simvastatin |
| Comment | Providing initial insight, we show that HMGCR loss of function is sufficient to enhance the Wnt pathway. Furthermore, we demonstrate that simva acts on Wnt signaling by depleting isoprenoids, rather than through a cholesterol-dependent mechanism. |
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Formal Description Interaction-ID: 51348 |
gene/protein decreases_activity of process |
| Drugbank entries | Show/Hide entries for HMGCR |
| Comment | Simva (=simvastatin) enhances Wnt signaling via depletion of isoprenoids and not cholesterol. Oral simva treatment enhances Wnt signaling in the mammalian adult hippocampus. This is significant in that aside from lithium, no other clinically approved compound has been demonstrated to enhance Wnt signaling in the brain. Addition of GGPP or FPP to simva-treated cells significantly reduced simva-mediated Wnt enhancement, while squalene did not have an effect. Since FPP is used to synthesize GGPP, the effect may be due to depletion of GGPP alone or a combination of FPP and GGPP depletion. |
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Formal Description Interaction-ID: 51477 |
drug/chemical compound decreases_activity of process |
| Comment | Simva (=simvastatin) enhances Wnt signaling via depletion of isoprenoids and not cholesterol. Oral simva treatment enhances Wnt signaling in the mammalian adult hippocampus. This is significant in that aside from lithium, no other clinically approved compound has been demonstrated to enhance Wnt signaling in the brain. Addition of GGPP or FPP to simva-treated cells significantly reduced simva-mediated Wnt enhancement, while squalene did not have an effect. Since FPP is used to synthesize GGPP, the effect may be due to depletion of GGPP alone or a combination of FPP and GGPP depletion. |
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Formal Description Interaction-ID: 51478 |
drug/chemical compound decreases_activity of process |