General Information:

Id: 5,266 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Metabolic
Mus musculus
article/cited
Reference: Robin NC et al.(2013) Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/beta-Catenin Signaling Stem Cell Reports 2: 9-17 [PMID: 24511465]

Interaction Information:

Comment Statins antagonize HMG-CoA-reductase (HMGCR), the rate-limiting enzyme in the sterol biosynthetic pathway. HMGCR loss of function is sufficient to enhance the Wnt pathway. (cited information)
Formal Description
Interaction-ID: 51340

drug/chemical compound

Statin

decreases_activity of

gene/protein

HMGCR

Drugbank entries Show/Hide entries for HMGCR