General Information:

Id: 5,265 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Reference: Choi H et al.(2008) Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT Cancer Sci. 99: 2518-2524 [PMID: 19018768]

Interaction Information:

Comment The results suggest that curcumin degrades AhR and ARNT redox-dependently through proteasomes, and that this impairs xenobiotic responses to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin).
Formal Description
Interaction-ID: 51345

drug/chemical compound


decreases_activity of

drug/chemical compound


in MCF-7 breast cancer cells, in Hep3B hepatic cancer cells