General Information:

Id: 5,265 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Choi H et al.(2008) Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT Cancer Sci. 99: 2518-2524 [PMID: 19018768]

Interaction Information:

Comment Previous studies demonstrated that oxidative stress facilitates the proteasomal degradation of ARNT. This study demonstrated that curcumin induced the proteasomal degradations of AhR and ARNT by increasing oxidative stress and subsequently abolished the TCDD-induced expressions of CYP1A1 and CYP1B1.
Formal Description
Interaction-ID: 51334

drug/chemical compound

Curcumin

increases_activity of

in MCF-7 breast cancer cells, in Hep3B hepatic cancer cells; via increased oxidative stress