General Information:

Id: 5,265 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Choi H et al.(2008) Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT Cancer Sci. 99: 2518-2524 [PMID: 19018768]

Interaction Information:

Comment TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a highly toxic environmental contaminant. When exposed to TCDD, mammalian cells undergo malignant transformation via abnormal intracellular signaling cascades, and the robust inductions of cytochrome P450 (CYP) enzymes are considered to mediate carcinogenesis by producing genotoxic metabolites. This study examined whether curcumin has preventive activity against TCDD-induced CYP production and cell transformation. The cellular levels of cytochrome P450 (CYP) 1A1 and 1B1 were examined, because these are known to generate estrogen metabolites that mediate genotoxic stress. In Hep3B (hepatoma) and MCF7 (mammary carcinoma) cells curcumin inhibited CYP1A1 and 1B1 induction by TCDD at the mRNA and protein levels.
Formal Description
Interaction-ID: 51320

drug/chemical compound

Curcumin

decreases_expression of

gene/protein

CYP1B1

in MCF-7 breast cancer cells, in Hep3B hepatic cancer cells; if expression was induced by dioxin