General Information:

Id: 5,264 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Beedanagari SR et al.(2009) Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes Toxicol. Sci. 110: 61-67 [PMID: 19376845]

Interaction Information:

Comment The studies indicate that resveratrol inhibits dioxin induction of the CYP1 family members either by directly or indirectly inhibiting the recruitment of the transcription factors AHR and ARNT to the xenobiotic response elements of the corresponding genes. The reduced transcriptional factor binding at their enhancers then results in reduced pol II recruitment at the promoters of these genes.
Formal Description
Interaction-ID: 51314

drug/chemical compound

Resveratrol

decreases_activity of

gene/protein

AHR

via decreased recruitment to xenobiotic response elements
Drugbank entries Show/Hide entries for Resveratrol or AHR