General Information:

Id: 5,264 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Beedanagari SR et al.(2009) Resveratrol inhibits dioxin-induced expression of human CYP1A1 and CYP1B1 by inhibiting recruitment of the aryl hydrocarbon receptor complex and RNA polymerase II to the regulatory regions of the corresponding genes Toxicol. Sci. 110: 61-67 [PMID: 19376845]

Interaction Information:

Comment MCF-7 and HepG2 cells were treated for 48 h with or without resveratrol and with or without dioxin and then analyzed for mRNA levels of the cytochrome P450s. Resveratrol treatment on its own did not affect the expression of the CYP1A1, CYP1A2, and CYP1B1 mRNAs. However, resveratrol significantly inhibited dioxin induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs in MCF-7 cells and CYP1A1, CYP1A2 in HepG2 cells.
Formal Description
Interaction-ID: 51311

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

CYP1A1

in MCF-7 breast cancer cells, in HepG2 hepatic cancer cells; if expression was induced by dioxin
Drugbank entries Show/Hide entries for Resveratrol
Comment MCF-7 and HepG2 cells were treated for 48 h with or without resveratrol and with or without dioxin and then analyzed for mRNA levels of the cytochrome P450s. Resveratrol treatment on its own did not affect the expression of the CYP1A1, CYP1A2, and CYP1B1 mRNAs. However, resveratrol significantly inhibited dioxin induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs in MCF-7 cells and CYP1A1, CYP1A2 in HepG2 cells.
Formal Description
Interaction-ID: 51312

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

CYP1B1

in MCF-7 breast cancer cells; if expression was induced by dioxin
Drugbank entries Show/Hide entries for Resveratrol
Comment MCF-7 and HepG2 cells were treated for 48 h with or without resveratrol and with or without dioxin and then analyzed for mRNA levels of the cytochrome P450s. Resveratrol treatment on its own did not affect the expression of the CYP1A1, CYP1A2, and CYP1B1 mRNAs. However, resveratrol significantly inhibited dioxin induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs in MCF-7 cells and CYP1A1, CYP1A2 in HepG2 cells.
Formal Description
Interaction-ID: 51313

drug/chemical compound

Resveratrol

decreases_expression of

gene/protein

CYP1A2

in MCF-7 breast cancer cells, in HepG2 hepatic cancer cells; if expression was induced by dioxin
Drugbank entries Show/Hide entries for Resveratrol or CYP1A2
Comment The studies indicate that resveratrol inhibits dioxin induction of the CYP1 family members either by directly or indirectly inhibiting the recruitment of the transcription factors AHR and ARNT to the xenobiotic response elements of the corresponding genes. The reduced transcriptional factor binding at their enhancers then results in reduced pol II recruitment at the promoters of these genes.
Formal Description
Interaction-ID: 51314

drug/chemical compound

Resveratrol

decreases_activity of

gene/protein

AHR

via decreased recruitment to xenobiotic response elements
Drugbank entries Show/Hide entries for Resveratrol or AHR
Comment The studies indicate that resveratrol inhibits dioxin induction of the CYP1 family members either by directly or indirectly inhibiting the recruitment of the transcription factors AHR and ARNT to the xenobiotic response elements of the corresponding genes. The reduced transcriptional factor binding at their enhancers then results in reduced pol II recruitment at the promoters of these genes.
Formal Description
Interaction-ID: 51315

drug/chemical compound

Resveratrol

decreases_activity of

gene/protein

ARNT

via decreased recruitment to xenobiotic response elements
Drugbank entries Show/Hide entries for Resveratrol