General Information:

Id: 5,254 (click here to show other Interactions for entry)
Diseases: Breast cancer - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000815 MDA-MB-231 cell
Reference: Goode GD et al.(2013) Knockdown of aberrantly upregulated aryl hydrocarbon receptor reduces tumor growth and metastasis of MDA-MB-231 human breast cancer cell line Int. J. Cancer 133: 2769-2780 [PMID: 23733406]

Interaction Information:

Comment Recent studies suggest a possible role for the aryl hydrocarbon receptor (AhR) in cancer independent of polycyclic aromatic hydrocarbons (PAH). Stable AhR knockdown cells of the human breast cancer cell line MDA-MB-231 were established and their tumorigenic properties were analyzed in in vitro and in vivo model systems. AhR knockdown attenuated these cells tumorigenic properties in vitro including proliferation, anchorage independent growth, migration and apoptosis and reduced orthotopic xenograft tumor growth and lung metastasis in vivo.
Formal Description
Interaction-ID: 51222



affects_activity of

in MDA-MB-231 breast cancer cells
Drugbank entries Show/Hide entries for AHR