General Information:

Id: 5,241 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Dominy JE Jr et al.(2010) Nutrient-dependent regulation of PGC-1alphas acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5 Biochim. Biophys. Acta 1804: 1676-1683 [PMID: 20005308]

Interaction Information:

Comment Overexpression of Sirt1 in the liver significantly increased the expression of PEPCK and glucose-6-phosphatase in a PGC-1alpha-dependent manner.
Formal Description
Interaction-ID: 51118

gene/protein

SIRT1

increases_expression of

gene/protein

G6PC

via PPARGC1A