General Information:

Id: 5,241 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Dominy JE Jr et al.(2010) Nutrient-dependent regulation of PGC-1alphas acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5 Biochim. Biophys. Acta 1804: 1676-1683 [PMID: 20005308]

Interaction Information:

Comment Activation of endogenous Sirt1 activity by resveratrol in cultures of C2C12 myotubes was able to induce the deacetylation of overexpressed PGC-1alpha protein and potentiate the effects of PGC-1alpha on MCAD, ERRalpha, and cytochrome c. Resveratrol, however, was not able to enhance the activity of PGC-1alpha when all 13 of the known acetylated lysine residues were mutated to an arginine.
Formal Description
Interaction-ID: 51110

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

PPARGC1A

via SIRT1 activation
Drugbank entries Show/Hide entries for Resveratrol