General Information:

Id: 5,232 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0000599 Hep-G2 cell
article
Reference: Ramos AA et al.(2008) Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay Toxicol. Lett. 177: 66-73 [PMID: 18276086]

Interaction Information:

Comment Quercetin and ursolic acid prevented DNA damage and had antiproliferative properties in HepG2 cells suggesting an anticarcinogenic potential for these compounds. The protective effects of quercetin against t-BHP-induced DNA damage seem to be due to both direct effects on t-BHP toxicity and to cellularly mediated indirect effects which reflect the potentiation of the cellular antioxidant defenses.
Formal Description
Interaction-ID: 50954

drug/chemical compound

Quercetin

decreases_activity of

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Comment Quercetin and ursolic acid prevented DNA damage and had antiproliferative properties in HepG2 cells suggesting an anticarcinogenic potential for these compounds. The protective effects of quercetin against t-BHP-induced DNA damage seem to be due to both direct effects on t-BHP toxicity and to cellularly mediated indirect effects which reflect the potentiation of the cellular antioxidant defenses.
Formal Description
Interaction-ID: 50955

drug/chemical compound

Ursolic acid

decreases_activity of

Comment Rutin did not have effects on DNA damage, proliferation or DNA repair at any level.
Formal Description
Interaction-ID: 50959

drug/chemical compound

Rutin

NOT affects_activity of

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