General Information:

Id: 5,226
Diseases: Cardiovascular disease
Homo sapiens
Human umbilical endothelial cells
article
Reference: Zhou Q et al.(2009) High-dose lovastatin decreased basal prostacyclin production in cultured endothelial cells Prostaglandins Other Lipid Mediat. 89: 1-7 [PMID: 19135546]

Interaction Information:

Comment Lovastatin induced a significant dose- and time-dependent decrease of arachidonic acid release from vascular endothelial cells.
Formal Description
Interaction-ID: 50922

drug/chemical compound

Lovastatin

decreases_quantity of

drug/chemical compound

Arachidonic acid

in vascular endothelial cells
Drugbank entries Show/Hide entries for Lovastatin or Arachidonic acid
Comment Lovastatin decreased significantly Ca2+ influx into the endothelial cell.
Formal Description
Interaction-ID: 50923

drug/chemical compound

Lovastatin

decreases_quantity of

drug/chemical compound

Ca2+

in vascular endothelial cells
Drugbank entries Show/Hide entries for Lovastatin
Comment 27-Hydroxycholesterol (27OHC) , an oxidized cholesterol, increased arachidonic acid release from the cells and stimulated Ca2+ influx after 6 h of treatment.
Formal Description
Interaction-ID: 50924

drug/chemical compound

27-Hydroxycholesterol

increases_quantity of

drug/chemical compound

Arachidonic acid

in vascular endothelial cells
Drugbank entries Show/Hide entries for
Comment 27-Hydroxycholesterol (27OHC) , an oxidized cholesterol, increased arachidonic acid release from the cells and stimulated Ca2+ influx after 6 h of treatment.
Formal Description
Interaction-ID: 50925

drug/chemical compound

27-Hydroxycholesterol

increases_quantity of

drug/chemical compound

Ca2+

in vascular endothelial cells
Comment Lovastatin diminished prostacyclin production and inhibited activity of cyclooxygenase-.
Formal Description
Interaction-ID: 50927

drug/chemical compound

Lovastatin

decreases_quantity of

drug/chemical compound

Prostaglandin I2

in vascular endothelial cells
Drugbank entries Show/Hide entries for Lovastatin
Comment Lovastatin diminished prostacyclin production and inhibited activity of cyclooxygenase-.
Formal Description
Interaction-ID: 50929

drug/chemical compound

Lovastatin

decreases_activity of

gene/protein

PTGS1

in vascular endothelial cells
Drugbank entries Show/Hide entries for Lovastatin or PTGS1
Comment Lovastatin induced an inhibition of phospholipase A2 (PLA2 ) activity.
Formal Description
Interaction-ID: 50930

drug/chemical compound

Lovastatin

decreases_activity of

gene/protein

PLA2G4A

in vascular endothelial cells
Drugbank entries Show/Hide entries for Lovastatin or PLA2G4A
Comment 27-Hydroxycholesterol (27OHC) , an oxidized cholesterol, increased PLA2 activity.
Formal Description
Interaction-ID: 50937

drug/chemical compound

27-Hydroxycholesterol

increases_activity of

gene/protein

PLA2G4A

in vascular endothelial cells
Drugbank entries Show/Hide entries for PLA2G4A