General Information:

Id: 518 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0002104 BE(2)M17 cell
article
Reference: Sandebring A et al.(2009) Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1. PLoS ONE 4: E5701 [PMID: 19492085]

Interaction Information:

Comment PINK1 can protect against rotenone toxicity, since cells expressing PINK1 showed improved viability after exposure of rotenone.
Formal Description
Interaction-ID: 2661

drug/chemical compound

Rotenone

increases_activity of

process

neuron death

Comment PINK1 can protect against rotenone toxicity, since cells expressing PINK1 showed improved viability after exposure of rotenone.
Formal Description
Interaction-ID: 2664

gene/protein

PINK1

decreases_activity of

process

neuron death

if cell death has been induced by rotenone