General Information:

Id: 5,186 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Mus musculus
male
C57BL/6 TgSMCnox1, with significantly increased Nox1 levels in vascular smooth muscle cells
article/cited
Reference: Dikalova AE et al.(2010) Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling Am. J. Physiol. Heart Circ. Physiol. 299: H673-H679 [PMID: 20639222]

Interaction Information:

Comment ANG II infusion inhibited endothelium-dependent vasodilatation in WT mice and worsened the impairment already present in TgSMCnox1 mice.
Formal Description
Interaction-ID: 50781

gene/protein

Angiotensin II

decreases_activity of

process

vasodilation

in cardiac aorta