General Information:

Id: 5,182 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Metabolic
Homo sapiens
BTO:0001949 HUVEC cell
article
Reference: Heinloth A et al.(2000) Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells J. Am. Soc. Nephrol. 11: 1819-1825 [PMID: 11004212]

Interaction Information:

Comment Addition of low concentrations of OxLDL causes an increase in proliferation of HUVECs of 250 to 300%. OxLDL and its compound LPC induce proliferation of HUVEC through activation of NADPH oxidase. The active NADPH oxidase generates O2-, which mediates the proliferative effects.
Formal Description
Interaction-ID: 50737

complex/PPI

OxLDL

increases_activity of

of endothelial cells; via increasing the level of O2-