General Information:

Id: 5,182
Diseases: Cardiovascular disease
Metabolic
Homo sapiens
BTO:0001949 HUVEC cell
article
Reference: Heinloth A et al.(2000) Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells J. Am. Soc. Nephrol. 11: 1819-1825 [PMID: 11004212]

Interaction Information:

Comment Addition of low concentrations of OxLDL causes an increase in proliferation of HUVECs of 250 to 300%. OxLDL and its compound LPC induce proliferation of HUVEC through activation of NADPH oxidase. The active NADPH oxidase generates O2-, which mediates the proliferative effects.
Formal Description
Interaction-ID: 50737

complex/PPI

OxLDL

increases_activity of

of endothelial cells; via increasing the level of O2-
Comment Diphenylene iodonium, an inhibitor of NADPH oxidase, prevented OxLDL-induced proliferation of HUVEC, indicating that NADPH oxidase was the source for enhanced O2- formation.
Formal Description
Interaction-ID: 50738

complex/PPI

NADPH oxidase complex

increases_quantity of

drug/chemical compound

O2-

in endothelial cells
Comment Diphenylene iodonium, an inhibitor of NADPH oxidase, prevented OxLDL-induced proliferation of HUVEC, indicating that NADPH oxidase was the source for enhanced O2- formation.
Formal Description
Interaction-ID: 50739

complex/PPI

OxLDL

increases_activity of

complex/PPI

NADPH oxidase complex

in endothelial cells; resulting in increased O2- levels and higher proliferation
Comment Addition of low concentrations of OxLDL and LPC enhance the O2- formation in HUVECs. Cells transfected with antisense oligonucleotides for NADPH oxidase showed a significantly reduced O2- formation after stimulation with OxLDL and LPC, indicating that NADPH oxidase is the enzyme responsible for O2- formation.
Formal Description
Interaction-ID: 50740

complex/PPI

OxLDL

increases_quantity of

drug/chemical compound

O2-

in endothelial cells; via inducing NADPH oxidase
Comment Addition of low concentrations of OxLDL and LPC enhance the O2- formation in HUVECs. Cells transfected with antisense oligonucleotides for NADPH oxidase showed a significantly reduced O2- formation after stimulation with OxLDL and LPC, indicating that NADPH oxidase is the enzyme responsible for O2- formation.
Formal Description
Interaction-ID: 50741

drug/chemical compound

Lysophosphatidylcholine

increases_quantity of

drug/chemical compound

O2-

in endothelial cells; via inducing NADPH oxidase
Comment Incubation of HUVECs with LPC significantly enhances cell proliferation.
Formal Description
Interaction-ID: 50742

drug/chemical compound

Lysophosphatidylcholine

increases_activity of

of endothelial cells; via increasing the level of O2-
Comment Addition of low concentrations of OxLDL causes an increase in proliferation of HUVECs of 250 to 300%. OxLDL and its compound LPC induce proliferation of HUVEC through activation of NADPH oxidase. The active NADPH oxidase generates O2-, which mediates the proliferative effects.
Formal Description
Interaction-ID: 50743

drug/chemical compound

O2-

increases_activity of

of endothelial cells