General Information:

Id: 517 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000793 SH-SY5Y cell; BTO:0000567 HeLa cell; BTO:0002393 N-27 cell (rat cell line transfected with human PINK1)
article
Reference: Vives-Bauza C et al.(2010) PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl. Acad. Sci. U.S.A. 107: 378-383 [PMID: 19966284]

Interaction Information:

Comment Cytosolic Parkin translocates to mitochondria upon exposure to CCCP or its analog FCCP.
Formal Description
Interaction-ID: 2558

drug/chemical compound

CCCP

increases_transport of

gene/protein

PARK2

into mitochondria
Comment Cytosolic Parkin translocates to mitochondria upon exposure to CCCP or its analog FCCP.
Formal Description
Interaction-ID: 2559

drug/chemical compound

FCCP

increases_transport of

gene/protein

PARK2

into mitochondria
Comment Parkin translocation into mitochondria after CCCP treatment is PINK1-dependent, but does not depend on DJ-1.
Formal Description
Interaction-ID: 2562

gene/protein

PINK1

increases_transport of

gene/protein

PARK2

into mitochondria; after CCCP treatment
Comment Parkin translocation into mitochondria after CCCP treatment is PINK1-dependent, but does not depend on DJ-1.
Formal Description
Interaction-ID: 2563

gene/protein

PARK7

NOT affects transport of

gene/protein

PARK2

into mitochondria; after CCCP treatment
Drugbank entries Show/Hide entries for PARK7
Comment Pathogenic PINK1 mutations, W437X and L347P, do not support Parkin translocation into mitochondria.
Formal Description
Interaction-ID: 2572

gene/protein mutant

PINK1-p.W437X

NOT increases_transport of

gene/protein

PARK2

into mitochondria
Comment Pathogenic PINK1 mutations, W437X and L347P, do not support Parkin translocation into mitochondria.
Formal Description
Interaction-ID: 2574

gene/protein mutant

PINK1-p.L347P

NOT increases_transport of

gene/protein

PARK2

into mitochondria
Comment Parkin binds to PINK1 without modifying each other.
Formal Description
Interaction-ID: 2579

gene/protein

PARK2

interacts (colocalizes) with

gene/protein

PINK1

in mitochondria
Comment Parkin does not increase ubiquitination of PINK1, nor does it promote its proteasomal degradation.
Formal Description
Interaction-ID: 2580

gene/protein

PARK2

NOT affects_ubiquitination/sumoylation of

gene/protein

PINK1

Comment Parkin does not increase ubiquitination of PINK1, nor does it promote its proteasomal degradation.
Formal Description
Interaction-ID: 2582

gene/protein

PARK2

NOT affects_quantity of

gene/protein

PINK1

via ubiquitin-mediated proteasomal degradation
Comment Overexpression of PINK1 causes relocalization of Parkin also in cells with normal membrane potential.
Formal Description
Interaction-ID: 2584

gene/protein

PINK1

increases_transport of

gene/protein

PARK2

into mitochondria; if PINK1 is overexpressed
Comment PINK1 and Parkin seems to be key elements of the mitochondrial trafficking machinery responsible for delivering defective mitochondria to the autophagy system.
Formal Description
Interaction-ID: 9824

gene/protein

PARK2

decreases_activity of

Comment PINK1 and Parkin seems to be key elements of the mitochondrial trafficking machinery responsible for delivering defective mitochondria to the autophagy system.
Formal Description
Interaction-ID: 45616

gene/protein

PARK2

increases_activity of

together with Pink1