General Information:

Id: 5,174 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Kemper MF et al.(2014) Genomic and non-genomic regulation of PGC1 isoforms by estrogen to increase cerebral vascular mitochondrial biogenesis and reactive oxygen species protection Eur. J. Pharmacol. 723: 322-329 [PMID: 24275351]

Interaction Information:

Comment The study examined a downstream target of PGC-1beta, glutamate-cysteine ligase (GCL), the rate-limiting enzyme for glutathione synthesis. In vivo estrogen increased protein levels of both GCL subunits and total glutathione levels.
Formal Description
Interaction-ID: 50633

drug/chemical compound


increases_quantity of

drug/chemical compound


in cerebral blood vessels
Drugbank entries Show/Hide entries for Estradiol or Glutathione