General Information:

Id: 517
Diseases: Parkinson disease
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000793 SH-SY5Y cell; BTO:0000567 HeLa cell; BTO:0002393 N-27 cell (rat cell line transfected with human PINK1)
article
Reference: Vives-Bauza C et al.(2010) PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl. Acad. Sci. U.S.A. 107: 378-383 [PMID: 19966284]

Interaction Information:

Comment Cytosolic Parkin translocates to mitochondria upon exposure to CCCP or its analog FCCP.
Formal Description
Interaction-ID: 2558

drug/chemical compound

CCCP

increases_transport of

gene/protein

PARK2

into mitochondria
Comment Cytosolic Parkin translocates to mitochondria upon exposure to CCCP or its analog FCCP.
Formal Description
Interaction-ID: 2559

drug/chemical compound

FCCP

increases_transport of

gene/protein

PARK2

into mitochondria
Comment PD-associated mutants (T415N, G430D) are not translocated into mitochondria after CCCP treatment.
Formal Description
Interaction-ID: 2560

drug/chemical compound

CCCP

NOT increases_transport of

gene/protein mutant

PARK2-p.T415N

into mitochondria
Comment PD-associated mutants (T415N, G430D) are not translocated into mitochondria after CCCP treatment.
Formal Description
Interaction-ID: 2561

drug/chemical compound

CCCP

NOT increases_transport of

gene/protein mutant

PARK2-p.G430D

into mitochondria
Comment Parkin translocation into mitochondria after CCCP treatment is PINK1-dependent, but does not depend on DJ-1.
Formal Description
Interaction-ID: 2562

gene/protein

PINK1

increases_transport of

gene/protein

PARK2

into mitochondria; after CCCP treatment
Comment Parkin translocation into mitochondria after CCCP treatment is PINK1-dependent, but does not depend on DJ-1.
Formal Description
Interaction-ID: 2563

gene/protein

PARK7

NOT affects transport of

gene/protein

PARK2

into mitochondria; after CCCP treatment
Drugbank entries Show/Hide entries for PARK7
Comment Pathogenic PINK1 mutations, W437X and L347P, do not support Parkin translocation into mitochondria.
Formal Description
Interaction-ID: 2572

gene/protein mutant

PINK1-p.W437X

NOT increases_transport of

gene/protein

PARK2

into mitochondria
Comment Pathogenic PINK1 mutations, W437X and L347P, do not support Parkin translocation into mitochondria.
Formal Description
Interaction-ID: 2574

gene/protein mutant

PINK1-p.L347P

NOT increases_transport of

gene/protein

PARK2

into mitochondria
Comment After adding CCCP to cells, the content of mitochondrial PINK1 increases, suggesting that mitochondrial depolarization may enhance PINK1 stability.
Formal Description
Interaction-ID: 2575

drug/chemical compound

CCCP

increases_quantity of

gene/protein

PINK1

in mitochondria
Comment Parkin binds to PINK1 without modifying each other.
Formal Description
Interaction-ID: 2579

gene/protein

PARK2

interacts (colocalizes) with

gene/protein

PINK1

in mitochondria
Comment Parkin does not increase ubiquitination of PINK1, nor does it promote its proteasomal degradation.
Formal Description
Interaction-ID: 2580

gene/protein

PARK2

NOT affects_ubiquitination/sumoylation of

gene/protein

PINK1

Comment Parkin does not increase ubiquitination of PINK1, nor does it promote its proteasomal degradation.
Formal Description
Interaction-ID: 2582

gene/protein

PARK2

NOT affects_quantity of

gene/protein

PINK1

via ubiquitin-mediated proteasomal degradation
Comment Overexpression of PINK1 causes relocalization of Parkin also in cells with normal membrane potential.
Formal Description
Interaction-ID: 2584

gene/protein

PINK1

increases_transport of

gene/protein

PARK2

into mitochondria; if PINK1 is overexpressed
Comment PINK1 and Parkin seems to be key elements of the mitochondrial trafficking machinery responsible for delivering defective mitochondria to the autophagy system.
Formal Description
Interaction-ID: 2589

gene/protein

PINK1

increases_activity of

together with Parkin
Comment PINK1 and Parkin seems to be key elements of the mitochondrial trafficking machinery responsible for delivering defective mitochondria to the autophagy system.
Formal Description
Interaction-ID: 9824

gene/protein

PARK2

decreases_activity of

Comment PINK1 and Parkin seems to be key elements of the mitochondrial trafficking machinery responsible for delivering defective mitochondria to the autophagy system.
Formal Description
Interaction-ID: 9825

gene/protein

PINK1

decreases_activity of

Comment PINK1 and Parkin seems to be key elements of the mitochondrial trafficking machinery responsible for delivering defective mitochondria to the autophagy system.
Formal Description
Interaction-ID: 45616

gene/protein

PARK2

increases_activity of

together with Pink1