General Information:

Id: 5,160 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Hsieh TC et al.(2014) Biochemical and Cellular Evidence Demonstrating AKT-1 as a Binding Partner for Resveratrol Targeting Protein NQO2 PLoS ONE 9 [PMID: 24968355]

Interaction Information:

Comment In studies to test whether exposure to resveratrol potentiates or diminishes AKT binding to NQO2, the authors showed that pre-binding by resveratrol in wild type but not histidine-161 (N161H) mutant NQO2 significantly affected this interaction. The results suggest that NQO2:AKT can exist intracellularly as a complex and the avidity of their reciprocal binding may be further modulated by exposure to resveratrol.
Formal Description
Interaction-ID: 50474

drug/chemical compound

Resveratrol

affects_quantity of

complex/PPI

AKT1-NQO2 complex

Drugbank entries Show/Hide entries for Resveratrol