General Information:

Id: 5,160 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
article
Reference: Hsieh TC et al.(2014) Biochemical and Cellular Evidence Demonstrating AKT-1 as a Binding Partner for Resveratrol Targeting Protein NQO2 PLoS ONE 9 [PMID: 24968355]

Interaction Information:

Comment In studies to test whether exposure to resveratrol potentiates or diminishes AKT binding to NQO2, the authors showed that pre-binding by resveratrol in wild type but not histidine-161 (N161H) mutant NQO2 significantly affected this interaction. The results suggest that NQO2:AKT can exist intracellularly as a complex and the avidity of their reciprocal binding may be further modulated by exposure to resveratrol.
Formal Description
Interaction-ID: 50474

drug/chemical compound

Resveratrol

affects_quantity of

complex/PPI

AKT1-NQO2 complex

Drugbank entries Show/Hide entries for Resveratrol
Comment AKT binds tightly to resveratrol, in line with its classification as a novel resveratrol target protein.
Formal Description
Interaction-ID: 50475

gene/protein

AKT1

interacts (colocalizes) with

drug/chemical compound

Resveratrol

Drugbank entries Show/Hide entries for AKT1 or Resveratrol
Comment The change on NQO2 levels following resveratrol treatments was examined. Exposure to resveratrol had no effect on NQO2, suggesting that control of NQO2 is distinct from regulation of AKT by resveratrol.
Formal Description
Interaction-ID: 50476

drug/chemical compound

Resveratrol

NOT affects_expression of

gene/protein

NQO2

Drugbank entries Show/Hide entries for Resveratrol or NQO2
Comment The half-life of AKT mRNA decreased from 4 h in control cells to 1 h in NQO2-knockdown cells. The inhibition of AKT by resveratrol was attenuated in NQO2-expressing relative to NQO2-knockdown cells.
Formal Description
Interaction-ID: 50478

drug/chemical compound

Resveratrol

decreases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for Resveratrol or AKT1