General Information:

Id: 515 (click here to show other Interactions for entry)
Diseases: Neurological
Homo sapiens
BTO:0000793 SH-SY5Y cell
article
Reference: Pan T et al.(2009) Rapamycin protects against rotenone-induced apoptosis through autophagy induction Neuroscience 164: 541-551 [PMID: 19682553]

Interaction Information:

Comment Rapamycin prevents against rotenone-induced cell injury.
Formal Description
Interaction-ID: 2549

drug/chemical compound

Rotenone

increases_activity of

process

neuron death

Comment Rapamycin prevents against rotenone-induced cell injury.
Formal Description
Interaction-ID: 2550

drug/chemical compound

Rapamycin

decreases_activity of

process

neuron death

if cell death has been induced by rotenone
Comment Block of autophagy by suppression of the autophagy gene Atg5, inhibits the neuroprotective effect of rapamycin.
Formal Description
Interaction-ID: 2552

process

autophagy

decreases_activity of

process

neuron death