General Information:

Id: 5,152 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephropathy, diabetic
Mus musculus
Reference: Kim MY et al.(2013) Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1alpha axis in db/db mice Diabetologia 56: 204-217 [PMID: 23090186]

Interaction Information:

Comment The results suggest that resveratrol prevents diabetic nephropathy in db/db mice by the phosphorylation of AMPK and activation of SIRT1-PGC-1alpha signalling, which appear to prevent lipotoxicity-related apoptosis and oxidative stress in the kidney.
Formal Description
Interaction-ID: 50432

drug/chemical compound


decreases_activity of


Nephropathy, diabetic

in db/db mice
Drugbank entries Show/Hide entries for Resveratrol