General Information:

Id: 5,152 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephropathy, diabetic
Mus musculus
Reference: Kim MY et al.(2013) Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1alpha axis in db/db mice Diabetologia 56: 204-217 [PMID: 23090186]

Interaction Information:

Comment Previous studies have shown that FOXO3a activation has an anti-stress and anti-apoptotic action via the enhancement of BCL-2 activity and the downregulation of pro-apoptotic BCL-2-associated X protein (BAX) activity. An increased level of phospho-FOXO3a Ser253 was noted in db/db mice. Resveratrol decreased the activity of class O forkhead box (FOXO)3a phosphorylation, which resulted in a decrease in B cell leukaemia/lymphoma 2 (BCL-2)-associated X protein (BAX) and increases in BCL-2, superoxide dismutase (SOD)1 and SOD2 production.
Formal Description
Interaction-ID: 50418

drug/chemical compound


decreases_phosphorylation of

mRNA/protein variant


in kidney; in db/db mice, at Ser253
Drugbank entries Show/Hide entries for Resveratrol