General Information:

Id: 5,152 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephropathy, diabetic
Mus musculus
male
article
Reference: Kim MY et al.(2013) Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1alpha axis in db/db mice Diabetologia 56: 204-217 [PMID: 23090186]

Interaction Information:

Comment Increases in the renal oxidative DNA damage and lipid peroxidation, as reflected by the renal and urinary 8-hydroxy-deoxyguanosine (8-OH-dG) and urinary 8-isoprostane concentrations, respectively, were observed in db/db mice. Resveratrol reversed the increase in renal apoptotic cells and oxidative stress, as reflected by renal 8-OH-dG, urinary 8-OH-dG and isoprostane concentrations.
Formal Description
Interaction-ID: 50416

drug/chemical compound

Resveratrol

decreases_quantity of

drug/chemical compound

8-Isoprostane

in urine; in db/db mice
Drugbank entries Show/Hide entries for Resveratrol