General Information:

Id: 5,152 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephropathy, diabetic
Mus musculus
male
article
Reference: Kim MY et al.(2013) Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1alpha axis in db/db mice Diabetologia 56: 204-217 [PMID: 23090186]

Interaction Information:

Comment The phosphatidylinositol-3 kinase (PI3K) level and activity, as well as the phospho-Akt Ser473/total Akt ratio were significantly increased in db/db mice. Resveratrol treatment of db/db mice decreased the PI3K level and phospho-Ser473 Akt /total Akt ratio compared with the levels of the db/db mice.
Formal Description
Interaction-ID: 50411

drug/chemical compound

Resveratrol

decreases_activity of

gene/protein

AKT1

in kidney; in db/db mice, via decreased phosphorylation at Ser473
Drugbank entries Show/Hide entries for Resveratrol or AKT1