General Information:

Id: 5,152 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephropathy, diabetic
Mus musculus
male
article
Reference: Kim MY et al.(2013) Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1alpha axis in db/db mice Diabetologia 56: 204-217 [PMID: 23090186]

Interaction Information:

Comment Resveratrol lowered the non-esterified fatty acids (NEFA) and triacylglycerol content of the kidney, and this action was related to increases in the phosphorylation of AMPK (at Thr172 of the alpha chain) and the activation of SIRT1-PGC-1alpha signalling and of the key downstream effectors, the PPARalpha-oestrogen-related receptor (ERR)-1alpha-sterol regulatory element-binding protein 1 (SREBP1).
Formal Description
Interaction-ID: 50405

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

PPARGC1A

in kidney; in db/db mice, via increased acetylated Lys-PGC-1alpha levels
Drugbank entries Show/Hide entries for Resveratrol