General Information:

Id: 5,152 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Nephropathy, diabetic
Mus musculus
male
article
Reference: Kim MY et al.(2013) Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1alpha axis in db/db mice Diabetologia 56: 204-217 [PMID: 23090186]

Interaction Information:

Comment Resveratrol ameliorated glomerular matrix expansion and inflammation. The levels of the pro-fibrotic growth factor TGF-beta1 and associated extracellular matrix type IV collagen and inflammatory cell glomerular infiltration were significantly increased in the db/db mice. All of the diabetes-induced renal phenotypic changes and inflammation seen in the db/db mice were reversed by resveratrol treatment. The significantly increased production of type IV collagen in db/db mice was reversed by resveratrol treatment.
Formal Description
Interaction-ID: 50393

drug/chemical compound

Resveratrol

decreases_quantity of

complex/PPI

Collagen IV

in kidney; in db/db mice
Drugbank entries Show/Hide entries for Resveratrol