General Information:

Id: 5,129 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Reference: Reybier K et al.(2011) Insights into the redox cycle of human quinone reductase 2 Free Radic. Res. 45: 1184-1195 [PMID: 21762045]

Interaction Information:

Comment The effects of modulators/inhibitors on the free radical production during the redox cycle of QR2 were studied. Resveratrol, melatonin and the synthetic compound S29434 were added to the system QR2/BNAH or NRH/menadione. In both cases, the addition of melatonin at 10 microM significantly increased • OH production. Resveratrol at 10 microM also produced a large increase in • OH generation (almost twice as much) with BNAH, and a decrease around 30% with NRH. The synthetic compound S29434 completely eliminated • OH production with both co-substrates.
Formal Description
Interaction-ID: 50335

drug/chemical compound


affects_activity of



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