General Information:

Id: 510 (click here to show other Interactions for entry)
Diseases: Dementia, Lewy body - [OMIM]
Parkinson disease
Synucleinopathy
Mus musculus
BTO:0001355 temporal lobe; BTO:0000601 hippocampus
article
Reference: Spencer B et al.(2009) Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinsons and Lewy body diseases J. Neurosci. 29 [PMID: 19864570]

Interaction Information:

Comment Transgenic mice overexpressing SNCA displayed increased levels of LC3 immunoreactivity, indicating Beclin 1 dependent activation of autophagy.
Formal Description
Interaction-ID: 2536

gene/protein

BECN1

increases_activity of

process

autophagy